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Recently, by using the SPEAC technique with co-culture of cells in drops and CRISPR-Cas induced genetic manipulation, Wheeler and collaborators (153) identified the amphegulin–IL33-ST2 pathway as another communication mechanism between microglia and astrocytes, relevant to the pathogenesis of MS

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520 The anti-tumor effect of liraglutide is related to its inhibition of the PI3K/Akt signaling pathway, as the activation of Akt is crucial for promoting cell survival and proliferation, and liraglutide can inhibit this process in a dose-dependent manner